Heroes:
Random Eternals (Ikaris or Thena, Sersi might be a bit 'too big for the room') or Inhumans (Medusa and Crystal were the most commonly used back then). Black Knight. Blade. Nova. Hercules. Hellstrom. Ghost Rider. Luke Cage & Iron Fist. Brother Blood.
Villains:
Mandarin. Sandman. Baron Mordo. Ghost. Baron Zemo. Abomination. Nightmare. D'Spayre. Bullseye. Kingpin. Tiger Shark. Diablo. Terrax the Tamer. Red Ghost. Melter. Unicorn. Steel Serpent. Dracula. Arnim Zola. Dragon Man. Mad Thinker. Gamora. Thanos!
And the idea of a rando Micronauts character like Prince Acroyear or Baron Karza, or Rom character like Hybrid (the mutant / dire wraith hybrid) or Starshine could be fun!