The Owl was intended to be Daredevil's archenemy by Stan Lee, but that role has since been usurped by Kingpin, Bullseye and the Hand. To be fair, the...
I feel like Marvel taking place in a "real world" setting is an advantage. I don't mean it's realistic, but rather it sets itself as being our world...
You can easily sell Doom as the next overarching big bad. That's what makes him great -- Doom is a human, and proves to be the most dangerous villain...