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#300.
Almost went with #400, but the retcon of May coming back kinda took the fire out of it.
Ignoring the fact that it was McFarlane in his early prime, I just loved seeing both Spidey and Venom in the black suit/symbiote duking it out.
[img]https://i.pinimg.com/736x/81/f7/a2/81f7a28f04305e87bd9fa4e337c6ff76--alien-costumes-the-aliens.jpg[/img]
[img]https://static.comicvine.com/uploads/original/3/39001/3809657-smvsv.png[/img]
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I went with #300 because Venom! I love #400 regardless of the retcon and #700 kicked off one of favorite years of Spidey, so it was a tough choice. Hoping #800 is at that level.
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When with 300. It was a toss up between that or 400. Both are amazing. But Venom lasted. Aunt may returned, Ben was killed for 20yrs. So issue 300 has more sticking power. That said Ben is my favote spider-guy, love that he's back and love his book.
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200 and 300 are my favorites on this list