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Seeing this:https://www.dynamite.com/htmlfiles/viewProduct.html?PRO=C72513028149401011 makes me want to see a crossover with every Martian in fiction:
Kl
The "Mars Attacks!" Martians
The "War of...

Joker tries to get back at Krillin by going after his wife.

It doesn't end all that well for Joker.

The Mandalorian + The Witcher.

Got to admit, when I saw the thread title I thought it was going to be about the Darkwing Duck villains.

The Spidey from the "Spectacular Spider-Man" cartoon takes on the leader of the Manhattan clan in, well, Manhattan

Wasn't there a comic where Mephisto trapped Galactus in his (Mephisto's) realm and Galactus' reaction was basically "Well OK, if that's how you want it..suppertime!"?

Both Longshot and Gladstone are blindfolded and placed in the center of Arcade's deadliest Muderworld. Who gets to the exit first based on sheer luck?

Vega and Balrog (Claw and Boxer) are hired to take down DD. Fight takes place in Hell's Kitchen.

Lower Decks, The Orville, and Galaxy Quest. Team up of the affectionate Star Trek spoofs.

Q has just finished his latest game on the Enterprise, when...
Q: Well, that was fun. What next?
(An alarm goes off. Q gestures and a pocket watch appears, with a seemingly infinite number of...

I have yet to see any evidence that Anakin/Vader's hatred of the foul, gritty sand was diminished between moviesm.:p

https://m.youtube.com/watch?v=2tLf1JO5bvE

I think this needs to be factored in. Would the fact that Sandman is made of the very substance that Vader so hates give Sandman an advantage, or would...

Two of the most terrifyingly powerful vampires in fiction finally clash. Who comes out on top?

Psychonauts/Doom Patrol.
Imagine Raz entering the minds of the various DP members to battle their various fears and psychosis. (For example, Rita's mindscape would look like a 40s era film set and...

Somewhat related to the above, Cave Guy from Freakazoid! meeting Ultra-Humanite from the animated Justice League. Odds are they forego any actual crime in favor of listening to classical music and...

Spider-Man / My Hero Academia-either young Peter joining the school as a student, or an older Peter serving as a teacher/mentor.

The Six ( Doc Ock, Vulture, Mysterio, Electro, Kraven, and Sandman) get
transported to the future Gotham City of Batman Beyond. Batman is not immediately aware of their presence, and the villains...

Darkwing Duck meets Duck Dodgers in a potentially universe threatening clash of egos.

Spectacular Spider-Man/Gargoyles
Farscape/MCU Guardians of the Galaxy
She-Ra and the Princesses of Power/ the Avatar-verse. Maybe even toss some Dragon Prince in for good measure.

Lord Havok vs. Dr. Doom
Dr. Diehard vs. Magneto
Tracer vs. Sabretooth
Gorgon vs. Doc Ock
Dreanslayer vs. Dormammu

*snicker* Touche.

The original Fantastic Four (+She-Hulk) + The New Fantastic Four (Spider-Man, Wolverine, Hulk and Ghost Rider). What is the strongest threat ( any universe) they could take on?

An idea my roommate came up with:
1986: A young FBI agent named Fox Mulder has just graduated from Quantico. His first assignment: Investigate strange goings on in the small town of Hawkins,...

I think you win the thread.

Mr. Mxyzptlk makes Grodd and Zod an offer: he will grant ultimate power to whichever one impresses him most in a cooking contest, using cod as the special ingredient. Who wins?