Depending on who's wearing the suit, we tend to get different story beats.
Jay: Straightforward Golden Age-style stories. Perhaps this is the reason that we've seen so few stories focused solely on Jay since the Golden Age.
Barry: Sci-fi hijinks, with LOTS of emphasis on the weird science.
Wally: Legacy, legacy, and more legacy. It's all about the journey of growing up.
Bart: Probably *should* have been humor, but much to everyone's surprise and dismay, his brief tenure put him in the exact opposite situation.
Buried Alien (The Fastest Post Alive!)