Technically, the Red Skull caused Secret Empire by teaching Kobik, a reality warper with the mental acuity of a child, that Hydra is the best thing ever. To a lesser extent, Maria Hill also contributed by capturing Kobik and creating Pleasant Hill. It definitely wasn't the fault of the heroes, but I could totally see Kobik being pissed off at humanity in general for using her so much and then screwing it up. A child would probably just high tail it out there after throwing a tantrum.
Also, didn't Hydra Cap get those Chitauri eggs just so the invasion would happen? Not a moral event horizon, but that's pretty messed up.