Marvel actually makes quite a bit of money from collectors by way of 1:2000, meet or exceed, retailer exclusive, etc variants. Marvel sells the comics at regular wholesale but they get thousands (sometimes up to 100-200K per issue) worth of extra orders thanks to the collector market. Caveat is the way Marvel implements their variant program poses greater risk for retailers. For every retailer that makes money from incentive variants, there's probably 10 or more that post a loss or barely break even on product cost.