On twitter, Rick Remender (X-Force, Uncanny Avengers, Venom) shared a pitch for a Spider-Man story that Marvel ultimately rejected. It featured Spider-Man against a group of psychotic bug-based villains who got their powers from the same radiation he did.
It's interesting to see what runs we could have had.
Part of the problem could have been timing. This was during Brand New Day, so it didn't necessarily fit Marvel's approach at the time (at that point, they were focusing on classic villains with the Gauntlet; this story might not mesh well with other co-writers.)