Merging Cale with an established, though somewhat obscure supervillain is sort of lazy storytelling, anyway. Ideally, Cale should rise or fall on her own merit and how popular she is with WW comic fans. I think adding a twist to her rather generic condition is a more conservative course, in some respects, because merging two less-than-beloved might ultimately waste TWO characters.
Considering its present lack of simple things, like a regular supporting cast, and I think the WW can afford to waste much of anything.