That ending really knocked me on my ass. I don't want to spoil it for those who haven't read this yet, but wow, if you haven't prepared to be floored. BPRD has had some really melancholy beats before but I don't think anything tops this, and what's beautiful about it is that it involves a character that, up until this issue, we didn't even know. Being taken aback by Hellboy's death, or Abe's comma, well that's just to be expected as they are characters we've been following for 20 years now...but to feel the same way for random town guy #3? That takes some serious skill.
Also, I definitely think that was the fungus from pickins.