Sakura Haruno vs Tsunade

[Sasuke Uchiha]

This is War Arc Sakura with her Byakugou Seal vs Tsunade.

Local: Valley of the End.

Condition: Last one standing is the winner.

[Estrecca]

If both pack enough strength to one-shot the other, as I suspect, this is pretty much a game of rocket tag.

Otherwise, Tsunade's regeneration jutsu, her ability to mess up Sakura's body with a touch and her almost certainly larger chakra reserves give Tsunade the winning odds.

[Iron_Twister]

To be honest, I almost forgotten Sakura's power-up since it was out of focus for the other things at hand.

I think Sakura has a major strength advantage (if I can recall, her attacks under the seal have drastically shot up) but I think Tsunade could mess up her game with her pressure point-ish attacks (since it messed up Kabuto's game for a while in their fight and while Kabuto quickly adapted, this is Kabuto we're talking about) and get the hit in while Sakura struggles with her movements being all jumbled.

But then again, I'm not sure about the speed. This reminds me to reread those chapters.

[Hazard]

Tsunade has the edge with her final seal boost, I guess.

[The Drunkard Kid]

When it comes to two hand to hand specialists, I'm going to bet on the one with decades more experience, who has also shown tricks like being able to scramble your neural system with a touch.

Sakura may be in the same league of power now, but skill and experience are still in her teacher's corner.