My idea would be
Marvel Knights: Every 1-4 months a new street level hero gets the spotlight and a story arc. (Daredevil, Moon Knight, Punisher...)
Amazing Spider-Man: Just one title
Spider-Man: Miles title
Earth mightyest heroes the Avengers: Just one Avengers book
Uncanny X-Men: Just one X book
Marvel Cosmic: A book featuring the cosmic characters like GOTG, Darkhawk, Shiár, Kree, maybe the Inhumans, and tell a big story where everyone is involved somehow.
Marvel Tales: Or some other title, featuring the bigger player like Thor, Iron man and so on in their own storys arcs.