I doubt there is much of anything that Bendis can say himself that could alleviate some people's fears. I'm afraid the only thing that might be capable of doing so is through what he does with Clark and the rest and that, unfortunately, is something that requires the passage of time. Until then people will be unsettled about everything that is said and frankly I don't believe anything makes their concerns out and out invalid. Heck, I share some of the concerns that have been voiced by people since Bendis was announced as the writer. Now having said that I also am willing to at least give him the chance to prove those concerns to have been wrong. Lois being separated from Clark could mean a lot of different scenarios and at the moment all we have is speculation.
There are a lot of ways this could be headed to be honest including that they are actually going through a rough patch in their marriage that requires them to step away from each other for a time to sort things out. It's not an impossible direction to take this in at all nor does it necessarily mean that it couldn't end in a divorce. Now I don't happen to think it will at all because I chose to believe that their marriage is a strong one that will weather this rough patch but that doesn't prevent me from also having a niggling doubt in the back of my mind that it could happen. (After all the people in charge at DC HAVE done some pretty boneheaded things in the past.)