What would you want to see?
I've said I'd like to see some sort of "Old Man Blade". But you don't want it to ring as a ripoff of what was done with Logan. Instead, I'd set it in a future where the Vampires have won and have divided the earth into territories (think Into the Badlands).
I'd very heavily borrow from Hara-Kiri and Jet Li's Hero and have Blade seek out a Vampire lord and present himself. He'd recount stories of taking out other Vampires, but the Vampire lord would not believe him, because Blade is presumed dead.
Yaddda, yadda, yadda, violence ensues, Blade kills the vampires and dies at the end.