Well, in issue 298 that guard does say "No kiddin'?" when Peter tells that Spidey used to be his bodyguard, could be just another way of "Oh really?", but I'm probably overthinking it.
Would be weird if there was another memory wipe, since Strange said it was a one time thing, guess it's once per Sorcerer Supreme
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Makes me wonder how many memory wipes were used in Marvel, I know of 3 so far, one used after Jessica "died" in her comics to make everyone forget her, which was undone, OMD/OMIT, and the one used for Daredevil to get his secret identity back, wonder if there are more.