Which villains would you want to see in the Fresh Start era?

Frankly, if this really is a Fresh Start, instead of using old stand bys like Dr. Doom, use the B-list villains, but do something different with them. It seems like DC is willing to take more chances in revamping their villains, then Marvel, where it often seems like the writers and the fans demand the villains be doing the same things they have doing for decades, since the 60s or the 80s or whatever.

Take a generic villain and make him or her more sympathetic or evil or noble or creepy, etc. Heck even have them do a different plan, how many times can Wizard form a Frightful Four before it gets old (it got old a long time ago), have him up his game and form a Frightful Fourteen. Maybe give some the villains a back story because they never received one in the past. A lot of these B-list villains could be far more compelling, if both fans and writers were willing to take a chance and want more from them.