It starts out with Ben confronting Alt-Reed over giving up when the world needs him the most leading to Reed angrily blowing up (literally) and yelling that he doesn't understand before tearfully breaking down saying how hopeless things are. Then Head of SHIELD Sue appears, she came came after being told about Ben and Johnny. She agrees with Ben about Reed giving up and when Ben asks about this universe Johnny the page ends with Sue looking sad and asking Reed "didn't you tell him?".
Next we see is Johnny contacting Rachna about them being in wrong place and we see her standing over a version of Dee (who we saw last issue), who is also in a hospital bed and doesn't have the lower half of her body. Rachna with a sad look agrees that there is nothing here for them. Sue warns that Doomlactus has devoured the last of the surviving colonies and is heading to earth and after a nice scene between her and Johnny she gets a message that it's starting.
We see the heralds of Doom, who are made in his image, attacking civilians and heroes (the heroes all having SHIELD insignia's because every hero is under SHIELD). Ben, Johnny, and Sue instantly leap into the fray shocking the other heroes of the Fantastic Fours return. During this Reed is taken by a herald and told that Doomlactus has sensed holes in the skin between universes, accusing Reed that he was trying to escape. Johhny saves Reed from the herald but expends his powers doing leading Reed having to parachute him down.
Once back on the ground Reed has found his confidence and decides to find a solution to Doomlactus. At that moment our Doom appears to offer his assistance as he's an expert on the subject. Rachna explains that Doom "tailgated" them to this universe. After Ben and Johnny vouch for him Reed agrees to work with him to beat Doomlactus. Reed asks Ben and Johnny to do some recruiting as they are the only ones who can because of their "familiar faces".
We then cut to a man on a farm and his dog alerts him to Ben and Johnny's presence. It turns out the man is Norrin Radd aka the Silver Surfer! The duo then get a unfriendly welcome from Emma Frost (who seems to be living with SS) as she thinks that two of them are impostors. After they tell her to read their minds she confirms they are telling the truth and she tells Norrin that the Silver Surfer is needed on more time. The issue ends with the ominous shadow of Doomlactus hovering over the people of New York.