Ruby Summers isn't a villain, and isn't a 616 character, but she is responsible for Trevor Fitzroy becoming evil and (because of his time traveling), a super villain in 616. She got him resurrected even though she knew what he would eventually do.
Trevor Fitzroy in the future of Ruby and Bishop is first a superhero who has saved mutantkind many times, but he gets killed, and Ruby makes Layla Miller resurrect him without a soul (thats Layla's mutant power, resurrecting things but without their soul), because they needed him to stop someone who wanted to kill all mutants. That (being resurrected without a soul), begins his corruption and journey into becoming an evil madman.