A long, only occasionally violated trope in Marvel's canon holds that the secret of the Super-soldier Serum that turned poor, frail Steve Rogers into Captain America died with it's creator, Abraham Erskine. The inability of others to fully recreate it begs the question of where it came from in the first place.
In my personal head canon, I settled on an explanation that duplicating the Serum was so difficult because the secret Erskine never divulged was that he'd somehow gotten his hands on a sample of the Inhumans' Terrigen. Erskine's creation, (in this interpretation) was actually derived from his study of this mysterious substance, which helps explain its instant transformation of Cap's physique.
Watching Avengers: Infinity War imposed another notion on me. There's a scene where Cap and Black Panther are running side-by-side, outdistancing everyone around them (pretty sure that's spoilage minimal), and it occurred to me that Cap and BP have generally been depicted as physical equals, both in comics and film. There are some differences, like BP's night-vision and tracking senses, or Cap's almost sixth-sense combat instincts, but in terms of strength, speed, agility and stamina, they've always been neck and neck. It puts me to wondering if an alternative explanation might be that Erskine got his hands on a sample of The Wakandan's Heart Shaped Herb?
Does anybody know of something written in canon that addresses this? If not, do you have a personal head-canon of your own about the serum's origins?