Yeah, they usually just mess with Ben and Johnny when it comes to relationship drama (Torch marrying a Skrull posing as Alicia, Thing's relationships with Sharon Ventura and Alicia etc), Reed and Sue occasionally splinter too (a Namor arc in the 60s where they almost divorced, and the Civil War split)
Bendis already said to Newsarama that once we get past the dramatics, there's going to be some fun stories with Lois and Clark in their new status quo, they both still love each other but are faced with making something new and unique work between them. It's all vague, I just wish the press would reflect the interviews more than trying to scare people. Bendis is'nt out to do damage.That said, I don't expect this issue to do anything negative to the relationship anyway. I'm even still on the fence on how far to take the "new dynamic" hype for face-value. But if it does mess with the relationship, that's why, because it rarely ever hurts.