New here...but this is a nice moment to recollect later as "this is where I come in". I am avoiding spoilers but addressing the stuff about the Insomniac Spidey new DLC:
I think the Insomniac thing is just a conclusion of the character arc on whether Peter overcomes his over protectiveness for her. He does in that moment, and that's what it's about. I don't think there's any deeper world-building than that. DLC Part 1 was about Peter and MJ's relationship with Felicia Hardy throwing a spanner in their works and she got a playable section there (which Miles didn't get in the DLC). So I don't think there's anything long-term there. They wanted to make the end about Miles that's all. And yes that final part is adorable. DLC as a rule doesn't introduce too big plot points for the sequel games. The major exceptions are the Dishonored games where the DLC are actual full sequels.
As for MJ being a journalist in 616. See I don't think the Lois Lane comparisons are a problem because
1) Spider-Man has more in common with Superman than any other character.
2) Modern Day Lois is herself inspired by Mary Jane : knowing the secret identity, being his confidant, marrying the hero, all that done by MJ first. Heck Amy Adams in Man of Steel is basically Ultimate Mary Jane, down to being part of Superman's origins and keeper from the start, having red hair (which granted some versions of Lois did before but still), which was never part of the Superman-Lois dynamic even in Post-Crisis. So some turnaround is fair play.
3) The DLC introduced a wrinkle that's not there with Lois and Clark. Superman being able to fly means that there's no real long-distance relationship where Spider-Man will always be in New York. So that's a nice dimension.
4) MJ was already someone who traveled a lot and saw more of the world than Peter did. So it's not much of a sense.
My personal feeling is that writers and artists simply didn't understand stuff about modelling and acting. Their attitudes were that girls in that profession are idiots. And Slut-Shaming is part of that. I remember reading Roger Stern's post BND mini-Comic about MJ in The Loves of Spider-Man, and it's got this very dated attitude about MJ being too pretty for a serious role which is not really so much of an issue in contemporary theater and so on. So there's a lot of stuff to do there. And in any case making her a reporter is more believable to me than making her (or for that matter Peter) a corporate executive. I'd like her and Peter to be co-workers at the Daily Bugle. I mean the Parker Industries arc in retrospect is a good case for something that could have not only been done with a married Spider-Man but would have been improved with one. At the same time you had Peter CEO, Bendis made MJ work at Stark, when obviously they should have worked together at Parker Industries and enjoyed for however short or long the status-quo a period of success and celebrity as a power couple and co-workers, and MJ being a little more comfortable with fame would have helped Peter over. There could also be competitive edges about the reverse in power-dynamics in relationship where MJ was the famous one and now Peter is famous and so on.