Marvel Cinematic Universe tie-ins
When announcing the series, Sherwood said that those behind the project had "worked very carefully" with Marvel Studios to ensure that "content-wise we are only enhancing" the MCU.Buck noted that "things that have happened on [Agents of] S.H.I.E.L.D. will potentially affect our show as well", but cautioned that he was focused on getting the new series "launched" before attempting any crossovers with other parts of the MCU. Buck further elaborated, "This exists all in the same universe. Even if we don't cross paths with, say, Agents of S.H.I.E.L.D. or characters from other shows, they are still out there. We all live in the same world. The same things that applied in other shows and occurred also apply to Inhumans as well." Elements carried over from Agents of S.H.I.E.L.D. include the alien writing associated with the Inhumans on that series, and the blue Terrigen crystals, which were designed to be consistent with their depiction on Agents of S.H.I.E.L.D. Loeb noted that Hawaii was chosen as the series' setting, in part because Marvel wanted Inhumans to occur in "a contained area" as "a way to minimize its impact on the rest of the MCU". He added that, as of the premiere of the series, there were no plans for the characters to interact with the Inhumans on Agents of S.H.I.E.L.D such as Daisy Johnson. The final episode of the series sees the destruction of Attilan and its people becoming refugees on Earth, similarly to Thor: Ragnarok which sees the destruction of Asgard. Both also expressed the same sentiment that a place is its people, not a location.