If Picard gets the D, he's in command of a glass cannon ship that when allowed can really go nuts on firing phasers and torpedoes...But really can't take hits when the shields are gone/bypassed. Galaxy class starships will only get more tank like by the time of the Dominion War...Seriously, those ships can be refitted into beasts when Starfleet tries.
But with the E? Yeah, Picard murders those heavily outdated ships.
...Unless all Kirks decides to board Picard's ship and go Kirk Fu on everyone while leading swarms of red shirts while multiple Bones and Spocks bicker among one another during the chaos.