I asked this same question over at the DC forum. Are there any female superheroes/supervillians out there for whom being a scientitst/inventor is a main part of their schtick?
Seems like there's oodles of guy mad-scientists and guy wonder-makers. The Leader. Mr. Fantastic. Iron Man. The Mad Thinker. The Wizard. Black Panther. GiAnt-Man. Spider-Man. Professor X. Forge. (the original) Baron Zemo. The Fixer. The list seems endless, but always...guys.
I'm not talking about characters that use technology they got from somebody else. I mean ladies whose power is essentially creating gizmos that qualify as superpowers.
The closest that I can think of is Moondragon. Others?