Been on a Fallout kick lately so seeing how this plays out.

Robert House just solidified territory in New Vegas, only to discover that there has been an increase in caravan attacks.

Digging a little deeper, he finds out about Supermutants and the Cathedral (from fallout one). They still have access to the F.A.V. Virus.

At the same time, The master finds out about New Vegas and starts amassing his forces to deal with them.

Who wins, whom do you root for and what is the results?

(using the games as canon