In the last years, Marvel has increased the number of its "Spider-Characters" in the most diversal ways. I believe something similar could be said about DC's "Bat-Characters". Personally, I don't care if there's a thousand spiders, because I keep in mind that no one can beat the original one. However, when I think in perspective, I believe the sagas of "Spider-Island", "Spider-Verse" and "Spider-Geddon" could cause the Marvel Universe to become a real "Spider-Nest". You see:
1º) "Spider-Island":
This story clearly had no other way to finish but finding a cure for the Spider-Virus and remove NY's spider-insanity. However, the story could end up with some people keeping the spider-powers after all. In my opinion, all those spider-characters created through the years in strange and weird ways could find an easy origin here, in "Spider-Island"; as characters who find an stable "symbiosis" with the Spider-Virus. Either that or maybe "improved" by it. As examples of "origins", we could have Mattie Franklin, Anya Corazon, Cindy Moon and even Miles Morales. As examples of "improved" we could have Jessica Drew (her own powers combined with Spider-Man's), Julia Carpenter (same as Jessica), Ezekiel Sims (losing his original powers to save his life but gaining new ones from the virus), or even Otto Octavius (so we can skip the creepy mind-transfer's part).
Another interesting twist from this story could be those who have been close to Peter Parker. The whole story came from a sick experiment caused by the Jackal, using Peter Parker's Spider-DNA. So, just like what happened with Mary Jane, it would be obvious for those who has been close to Peter Parker to have some kind of "immunity" to his DNA. Seeing the different persons who could have take Peter's place in other dimensions, I guess some of those who could have found a "stable infection" in Spider-Island and gain the own Spider-Powers. On that least we could put Aunt May, Betty Brant, Flash Thompson, Hobie Brown, Gwen Stacy and Mary Jane Watson.
2º) "Spider-Verse":
It's really sad that, because of the Inheritors, several Spiders through the multiverse were killed, and the worlds of some others destroyed. That gave me an idea to help them have a chance. Considering that there was a lot of Spiders in Earth-616 after Spider-Island, the essence or spirit of several of those spiders are transfered to their counterparts in Earth-616. That way, the infection of their "spider-virus" turns estable on them. We would have the same characters close to Peter Parker: Aunt May, Betty Brant, Flash Thompson and Gwen Stacy. The transfer could also repair the damage of some characters, like Flash Thompson losing his legs. Some cases could even have interesting results; for example, the life of the Assassin Spider-Man being transfered to Kaine. Kaine is basically a dark version of Spider-Man and Peter Parker, so the life or Assassin Spider-Man seems fitting to him.
Several survivors Spiders who lost their worlds could also have a new home in Earth-616, especially those who are spiders from different countries. I would include in the list Spider-UK (in London), Spider-India (in India), Aracnido Jr (in Mexico), Kwaku Anansi (in Africa), and probably some of the Japanese Spider-Man, like Takuya and Leopardon.
3º) "Spider-Geddon":
I still have to read the whole story, but the increasing number of Spiders on Earth-616 could seem like the perfect excuse for the Inheritors to escape and invade this dimension. Don't you think?
Well, what do you think?