Fresh start has largely been pretty good.
Amazing Spider-man, Venom, Captain America, Sentry, Immortal Hulk, Dr Strange, Iron Man have been excellent. Even minis like Cosmic Ghost Rider, Death of Inhumans and Life of Captain Marvel have been a lot of fun. While i have a problem with Thor's characterization in his book, I've really enjoyed the book overall.
I haven't kept up with the X-books so I can't comment on them (and I don't think they were relaunched with Fresh Start except for X-23).
The only books that I've read and not largely enjoyed are Avengers and Deadpool (seriously, this book hasn't really dropped off since Duggan left).