Yeah, Blob has this. This is a guy who goes toe to toe with Colossus and gives him an even fight. Blob's also faster than he looks and he has the ability to catch fists with his body, so getting into a fist fight with Blob is a very bad idea for Luke.
Also, going up the side of a building is probably another bad idea, given Blob can just start chucking cars into the building until it and Luke come crashing down. The environment helps Blob too.
Luke's best bet is to run to the 4 Yancy Street (which I believe is the current HQ of the FF), and throw Ben Grimm at Blob.