Doom's abscence after the end of the first game,allowed the rise of Lucia von Bardas and the beginning of the game version of Secret War. Galactus cliffhanger in the end of MUA was referenced in a dialogue with Thor in Avengers Tower. So,there was a connection. I feel this game will ignore the previous continuity and start in a zero point.It's more easy than expalining Nick Fury's race differences or the abscence of FF.