I was thinking of Spider-Man/Human Torch. Only there because it's canon to 616 means that Slott had to compress all the actual Spider-Man/Torch interactions across the decades into a complete whole that is continuous on a sliding time scale. And of course there you have the hook of the Spider-Man/Torch friendship and to a large extent its more Johnny Storm's book than Peter's.
Grand Design is intended to summarize and contextualize X-Men's massive history and in the case of X-Men you don't have sliding time scale as much, you do have characters aging and progressing. Like Magneto is always a holocaust survivor, he and Charles first met in the '60s, Cyclops, Jean and others were teenagers who became adults/parents/exes. Wolverine is an immortal.I don't think he needs to be super extensive in Spider-Man history in order to tell this story, this isn't like Ed Piskor's X-Men Grand Design epics, though I would absolutely LOVE to see something like that for Spider-Man too.
Whereas with Spider-Man you have a character who is from the '60s and indeed a '60s icon (college kids were known to say, Spider-Man meant as much as Bob Dylan back then) and many of his early stories are situated in the '60s and '70s gradually becoming unmoored from that time especially Post-OMD. Pre-OMD where Peter was near his 30s and being a fair bit away from both his teenage and college days still made some sense but Post-OMD he's de-aged a fair bit.
Likewise Spider-Man is the quintessential New Yorker and New York is a city that has changed rapidly and dynamically decade-from-decade and especially Peter's circle of the newsmedia, academic world, and others were especially affected by those changes and yet nothing of that came in. Like Stonewall Riots happened in Greenwich village, and ESU (the stand-in for NYU) is located there...that was a mob controlled gay club and so on, and in Spider-Man in the Lee-Romita we see Kingpin own a club as a front which checks out but there's no hint of any of that affecting Peter. And of course the AIDS crisis was a big deal in New York, and especially the fashion industry which Mary Jane was part of, but we don't see that there. Then of course you have gentrification and Peter should ideally have moved out of the city because he's not believable anymore as a poor scrapping New Yorker. Crime rates and others have fallen which means that Spider-Man shouldn't really be such a stressful job for him. By the time Peter comes to the '90s, he can legitimately hang up his webs because the kind of street crime that he fought and defined him was part of the Taxi Driver era of New York and that has gone.