I was also thinking of doing a rumble between Manfred Richthofen (Red Baron) and Kara Thrace of the Battlestar Galactica remake. The problem is, each has a big advantage in their respective vehicles even if we comp the opponent the ability to fly the other vehicle.
And just saying "comparable vehicles" doesn't give commenters all that much. So I was searching for an in-between. But nothing sounded remotely plausible. For example: They hook up to the Matrix and each imagines they're flying their own vehicle (triplane, viper), but the VR program makes it work, so you get a duel of pure skill? Sounds phony.
You'd need to come up with a flying vehicle that both are unfamiliar with, they both get a chance to train with it for a time, then they're off. But what are they flying, specifically? Comparable vehicles.
Or in the above rumble, comparable firearms.
In any event, it looks like the Firefly crew has a significant skill and teamwork advantage no matter what firearms are used, standard or blasters.