Well they could clearly stand to elaborate on that character.
What if Otto Octavius remained as The Superior Spider-Man?
What if Spider-Man was a JRPG?
So hypothetically, if Peter's power-draining serum had worked as planned in issue 100 and he married Gwen without having to worry about being Spider-Man, what would happen the next time a supervillain attacked, or worse, Norman got over his amnesia again?
What if Otto stole a different Spider Heroes' body? ie Miles, Anya, Kaine
What if Flash Thompson/Agent Venom became a villain?
What if Black Cat and Jameson became a couple?
What if Peter ran the Daily Bugle?