It'd be interesting to do a Spider-Man mini-series about a Peter Parker dragged into an interdimensional conflict (the next Spider-Verse/ Spider-Geddon) shortly after he got his powers, so he goes back to his world knowing what might happen in the future (IE- A second-story man threatens his uncle's life, Norman Osborn is the Green Goblin, Otto Octavius will be turned into a monster by accident, Anna Watson's niece is surprisingly attractive.)

It'd be like What if Spider-Man read the comics?