Considering the crypto-homoerotic subtext read by some fans into Spider-Man's interactions with his rogues gallery, or his rogues' obsession with him, pulling a Superior on a female spider-powered hero with close and intimate knowledge of Peter Parker would be nine different kinds of disturbing yet intriguing (and intriguingly messed up).
The spider is always on the hunt.
Indeed it would be. I'd like to give the concept a whirl. That said, however, I don't think Cindy replacing Peter for Superior Spider-Man would work chronically given the established timeline. I would need to use MJ (who never gave up her Spider-Island powers), Black Cat, or maybe Jessica Drew (616 version, of course).
"So you've come to the end now alive but dead inside."
What if somebody other than some no name thug killed Uncle Ben, like in the film when it was Sandman?
Someone who stands closer to the side of good killing him could actually be interesting, like Deadpool.
I can now confirm that last year's two Spider What Ifs were great.
I don't blind date I make the direct market vibrate
What if Richard and Mary lived or were never framed as traitors, and were bitten alongside Peter as they accompany him to the science exhibition?
A whole different Spider-Fam.
What if nobody had been bitten by the radioactive spider?
What would like be like for Peter without ever having got any powers? What will he and May do once Uncle Ben dies? Who's going to handle the enemies that Spider-man normally fights?
What if Peter's parents were alive and partners with Hydra and the Red Skull
What if Spidey and Black Cat actually got married
What if Spidey became one of Galactus' Heralds
What if Spidey and Ms. Marvel became a thing again.
I think Peter would have gone the Punisher route. For example, He ignored his responsibility to stop the burglar and Ben was killed because of it... it taught him how he had a responsibility to use his powers to stop anyone else from getting hurt...
If anyone ELSE had killed Ben... if it wasn't really PETER'S fault? That lesson wouldn't be there and he'd have become the angry child lashing out at the unfair world.. Doc Ock thinks he has powers... Wait till they meet ME. I'll show them REAL power...
OR he'd have stayed in show business to help May with the bills... after all, Ben's death wasn't HIS fault...
Or possibly both.