Given the story hickman is doing it's a real possibility though if not romatically connected i do hope she keeps her place in the wakandan mythos but even without that she is still an African Goddess to many villages. For all ntents and purposes despite what most people think this is definitely a reboot for the x-men and two things have already happened in this story. Tchalla has been aged up somewhat more as he did live years in the past and it was mentioned Storm wasn't there for his return because she chose to go to the x-men. Which makes her not so innocent the grand scheme of things. She knew Tchalla was coming home, she hadn't seen him in awhile but rather than stay and see him first she left to handle x-men business and then come back. Showing she has priorities over Tchalla. Something Coates hasn't really leaned in on at all yet.
IF House of X ends with krakoa being what it is it can also creates problems. Storm is an American Citizen, A Kenyan Princess, a citizen of KAroka, where does wakanda fit on that list and how do they react to it. I would love to see storm reclaming her people lands in kenya in placing a karoka habitat seed there.