An old Spider-Man annual had a list of the best villains, and #1 wasn't any particular bad guy, but the Goblin brothers.
https://www.comicartfans.com/gallery...?piece=1415853
This was before we had any stories with multiple Goblins, so they were all lumped together, because Spider-Man would only fight one at a time.
The Goblins are now seen as very distinct, with Norman Osborn being a different character than Harry to say nothing of Roderick Kingsley.
But this leads to an interesting question: What are the best Goblin stories?
I've come up with a top ten, although it quickly becomes obvious that there are a lot of good honorable mentions, even when combining several big stories into larger sagas.
10. The Return of the Green Goblin (Amazing Spider-Man Volume 1 #17)
9. The Green Goblin Lives Again (Amazing Spider-Man #136-137)
8. Caged Angels (Thunderbolts #110-121)
7. Spidey and the Green Goblin Both Unmasked (Amazing Spider-Man #39-40)
6. Red Goblin (Amazing Spider-Man Volume 4 #32, #794-800)
5. Death of Spider-Man (Ultimate Spider-Man #156-160)
4. Down Among the Dead Men (Marvel Knights Spider-Man #1-12)
3. The Harry Osborn Saga (Spectacular Spider-Man #178-200)
2. The First Hobgoblin Saga (Amazing Spider-Man #238-251)
1. The Night Gwen Stacy Died (Amazing Spider-Man #121-122)
What are your favorites?