Actually Stark antagonizes powerful people all the time. He antagonizes SHIELD and the government by refusing to give them his best inventions. He antagonizes the board of directors by refusing to go back into the arms business. It's often really clear that Stark is only rich because his inventions are so good that even the money from his minor, safest inventions can financially power his company to an insane degree that more than compensates for how often he pisses people off.
What on earth are you talking about? She wasn't any angrier than any of the white super-genius types are when someone barges into their laboratories. If anything, she was calmer than Stark would usually be. Stark is not the type to gladly suffer fools, at all, whatsoever.