While I know that this thread will probably be largely "Classic Coke" Granny, fans should at least think over looking into the recent Tom King series.
There is some really quality Granny in that title.
Who can't love a big old Granny with superhuman strength?!?
And, I will never forget Edward Asner as the voice of Granny!
from Who's Who in the DC Universe #4 (November 1990):