Best rogues gallery...

[numberthirty]

While it's not exactly a "Garden Variety..." rogues gallery, Aqua Teen Hunger Force.

[Riv86672]

For me, it's Darkwing Duck. In fact one of my main attractions to the show was how they featured an amazing set of villains.

Megavolt
Quackerjack
Steelbeak (my personal favorite)
Negaduck
Bushroot
Liquidator
Splatter Phoenix
Professor Moliarty
Taurus Bulba
Tuskernini

etc.

Powerpuff Girls also had a pretty solid rogues gallery.

Darkwing even had his own Pennywise in Paddywhack!

But yeah, DW and the PPG really made their bones on their amazing rogues galleries.

[TheRay]

Agreed. You can never go wrong with Mojo Jojo.

He’s an absolute good. I would really like to see him used in crossovers.