No. The cartoon stars Peter, Miles, Gwen, and Anya.
She is in the MCU though (in Spider-Man Homecoming and Avengers Infinity War), albeit without her powers, so her role is very minor.
Rookie is right. It's telling that instead of ending up on an Avengers team, she became the first person past their teens to join the Champions Reinforcement Roster (and only, so far). Also, it's notable that Spider-Woman and Mockingbird, who are peers of hers, call her "kid", which is due to her inexperience and the fact that being stuck in the bunker means she still acts like a teenager at times.
It was definitely a mistake signing her up to SHIELD, considering that status quo was kaputted by Secret Empire prior to her joining the Spider-Man/Deadpool cast.