Well, since today had been International Women's Day, a question that I've been trying to answer is: What female villains does Spider-Man have?
I'm not talking about every female he's fought, mind you. I'm talking those ladies who began by fighting Spider-Man or have become associated with being primarily an adversary of Spider-Man. I'd also leave out Felicia "Black Cat" Hardy from this because she's been both an adversary and an ally of Spider-Man from time to time.