I would have expected to see some of these Spider villains show up as some of the Hunted, Badger Teeth, Boar, Bruin, Devil-Spider, Fly, Griffin, Grizzly, Human Fly, King Bee, Legal Eagle, Mandrill, Ox, Queen Cat, Razorback, Scorpia, Swarm, Vermin and the Vulturions. I guess the only animal themed villain of the Hateful Hexad to be killed off and stayed dead was Bearboarguy who could have returned here only to die again. With new animal themed villains showing up each issue i guess any of these are still possible.
https://marvel.fandom.com/wiki/Bearboarguy_(Earth-616)