I don't think they'll attempt it for a while. Probably not until they get the all the Fox properites. A meeting of the Avengers, X-Men and Fantastic Four would probably be the only thing potentially more epic than what we got in INfinity War and End Game. And I say potentially, because those are big shoes to fill.
Until then they can downscale a notch. Something more low key like Secret Invasion I think can work.