Tony apparently has access to the magic super metal, plus he developed an Infinity Gauntlet that seems comparable to one crafted by the dwarf that forged Stormbreaker, which seems stronger than Cap's shield going by how it was unharmed from from going edge to edge with Thanos' blade, but with more customizable features. Not to mention that he is smart enough to have figured out time travel by himself without even having access to Pym Particles or the Quantum Zone.
But no, Thanos is nowhere near as durable as his comic counterpart, who would have ignored everyone in the MCU, short of maybe Dormammu, wailing on him at once.