Ending of Captain America - First Avenger. Poor Steve fights his way outta the Shield hospital and into a world that has changed, with everyone he knew dead and gone

Soldier - 1998 Kurt Russell sci-fi flick. A soldier trained from birth to kill is literally thrown on the scrap heap and is so damaged inside he has trouble relating to the squatters occupying the junk world and is cast out all alone.

Life - 1999 Eddie Murphy/Martin Lawrence film. I spend the last half hour crying my eyes out over this comedy! The decades fly by and the two wrongfully jailed pair grow older and lose their friends.

When Marnie was there. The opening and the sweet but sad song at the end have me bawling my eyes out. Very shy, quiet person as a child and as an adult so this really hit HARD.
Also the fact this is the final (?) Ghibli Anime film pushed me over the edge.

and YOU?