Since MCU Thanos is getting so much attention it only makes sense to me to pit him against the pro heroes from My Hero Academia, so no students here.
Thanos does not have the gauntlet or infinity stones. He has his armor and cool yet ridiculous double sword. He is alone, because there aren't quite enough pro heroes to take on his army.
There are three fights that take place in the giant crater from Endgame.
1. Thanos vs. Pro Hero team (Kamui Woods, Mt. Lady, Endeavor, Gran Torino, Fatgum, Ryukyu and Hawks)
2. Thanos vs. All Might(All Might's powers won't crap out on him)
3. Thanos vs. All Might (same as above), Kamui Woods, Mt. Lady, Endeavor, Gran Torino, Fatgum, Ryukyu and Hawks
Bonus fight: Same as 3, except Thanos has the Black Order backing him up.