In the 1980s Cannon Films (which produced B-list horror films) had the option for Spider-Man, and was interesting in adapting the character as a knock-off of Cronenberg's The Fly. They had director Tobe Hooper (Texas Chainsaw Massacre) on-board, but it just didn't work out.

https://www.comicbookmovie.com/spide...1PpPN7fHxENWFg

This is an interesting dodged bullet. Even if it had been terrible, it would have been one of the things that defined Spider-Man.