You might find this idea quite crazy, but I just thought about a potential plot coming from the whole Spider-Verse's stuff. 616's Peter Parker has lose many beloved ones, like Uncle Ben, Gwen Stacy and many others. But how about if, in a twisted way, could cause history to be rewritten and the dead ones would be revived? Let me explain:
During the first Spider-verse, we know the Inheritors destroyed and conquered many realities; at the same time they killed many spiders. Well, how about if such action would have a consequence in the Web of Life and Destiny? Before being totally killed, the essence's remains from the dead Spiders is channelled through the Web until they reach Earth 616, where lies the only Spider who was able to defeat an Inheritor (Morlun). As a consequence, that essence merges with the counterpart of the killed spider; probably at a deadly moment, which causes its life to be salved. For example, the essence of the Spider-Man who was Captain George Stacy travels to Earth-616 after an Inheritor killed him. Then, when 616's Captain Stacy was going to die (because of the incident with Doc Ock), the spider essence of his counterpart gives him the strength to survive.
That essence remains "latent" inside the 616's counterparts of the spiders, until we came to the events of Spider-Island; as the infection of the Jackal's experiment causes a "rebirth" of the dead spiders inside the counterparts. And because of this, unlike the others, the infection stays stable in them; without the danger of mutating into Man-Spiders. With this, we could have a world where Captain George Stacy, Gwen, Betty Brant, Flash Thompson and several others got Spider-Powers. Quite crazy, huh?
What do you think of this idea?