I mean if anything I see it as an opportunity for them. If a writer wants to do a story with a bad guy doing what would have previously been a Loki kind of thing, but he is no longer available cus he's doing his anti-hero thing, there are options available. Maximus for broader MU stuff, maybe Enchantress for Asgard stuff. But they can make it their own thing, and it gives them an opportunity to show what they've got, rather than just use Loki again doing the same sorts of things he's already done many times before.