Perosnally the bit with Punisher than always gives me a good chuckle was from Genis' Captain Marvel bit that really played up how messed up Frank was.
He goes and kills a man who used to be some form of criminal but who since reformed and is just living a quiet life, possibly as a religious leader. But the real kicker was Punisher got some of Genis' cosmic awareness and sees the likely future. That mans son grows up and kills Frank. So it ends with Frank pleading for his life to a child who's only like 10.
But what it really shows is Punisher's own actions will inevitably result in his own death and worse creates criminals out of the friends and family of those who he kills which seems fitting and really always cemented me as Frank being a villain who just kills "bigger" villains.